CBC

CBC

The last two posts have outlined CBG and CBN, two lesser-known but highly important cannabinoids. We’ll continue this cannabinoid mini-series by detailing another notable one, CBC. Cannabichromene (CBC) is non-psychoactive cannabinoid that was first discovered in 1966. Similar to CBD, CBC is believed to interact with the body’s endocannabinoid system, which plays an important role in regulating one’s biological functions. CBC binds well to the body’s TRPV1 and TRPA1 receptors, which are linked to pain perception. This binding specifically increases the natural endocannabinoid production, allowing the endocannabinoid system to maintain its desired state of homeostasis. Let’s get into the specifics of how CBC may be of use in your day to day life.

CBC is thought to be a terrific inhibitor of acne by reducing the production of sebum in the body’s sebaceous glands. High levels of sebum result in blackheads, whiteheads, and other various forms of acne. A 2016 study supports these beliefs, noting “CBC, CBDV and especially THCV show promise to become highly efficient, novel anti-acne agents.”  In addition, CBC is said to hold anti-inflammatory properties, which should also help combat those pesky pimples.

The anti-inflammatory qualities of this cannabinoid extend far the ability to help clear up acne. Research suggests that CBC may  specifically reduce intestinal inflammation. It might also lessen stomach related matters including diarrhea and bloating. Further studies are certainly necessary, but CBC may prove to play a vital role in future treatments of gut related issues including food allergies and certain autoimmune diseases.

Research indicates that CBC may also have a positive influence on the brain. A 2013 study showed that the presence of CBC had a direct effect on NSPCs, which are critical to proper brain function. NSPCs convert into central nervous system cells, which fight against neurological diseases and brain disorders.

Finally, this particular cannabinoid is believed help with stress related issues. A 2010 study done by the University of Mississippi indicated that test subjects who were administered CBC showed improved stress test results compared to those who were not given CBC. Hopefully, these findings will lead to natural, effective ways to combat depression and other mood disorders.  As additional research continues on this particular cannabinoid, it’s therapeutic uses appear to be encouraging. The medical community has displayed an increase in interest with CBC and we’re optimistic that their findings will uncover further benefits.  

References:
https://www.ncbi.nlm.nih.gov/pubmed/27094344
https://www.ncbi.nlm.nih.gov/pubmed/23941747
https://www.leafly.com/news/cannabis-101/what-is-cannabichromene-cbc-cannabinoid

CBN

CBN

In the previous article, we discussed the benefits of the lesser-known cannabinoid, CBG.  In this post, we will highlight the cannabinoid CBN, or Cannabinol.  CBN is best known as the cannabinoid that forms as THC matures and ages.  When THC is exposed to oxygen, the degradation process turns THC into CBN. No need to be alarmed, CBN contains zero THC as the compound makeup becomes different altogether.  Compare this transformation to that of fine wine…age is better!  

CBN was first identified by Robert Sydney Cahn in the 1930s and was one of the first cannabinoids to be studied and researched.  People originally believed CBN was responsible for the “high” associated with THC.  Like all other cannabinoids, it is thought to interact with your body’s endocannabinoid system causing a desired effect.  Let’s dive into the potential benefits of CBN below.

CBN is said to be the most effective cannabinoid in terms of sedation.  Early research dating back to 1976 supports CBN’s efficacy in combating sleep related issues.  Additional studies done on test subjects have shown that CBN can assist in extending sleep time.  A 2017 study done by Steep Hill Labs found that CBN may provide the same results as pharmaceutical sleep medication minus the negative side effects.  Further research surrounding is certainly necessary regarding sleep and CBN, but initial findings look to be very promising.

The anti-inflammatory properties of CBN also appear to be evident.  Test subjects with experimental asthma showed a reduction in inflammation and a lessening of lung mucus production.  These anti-inflammatory benefits could also extend to other parts of the body including joints and the eyes.

In addition, CBN is thought be helpful for bone healing and growth.  Studies show that it may promote bone growth by activating stem cells.  This may also indicate its potential use in helping with bone fractures and osteoporosis.

As further studies are done on Cannabinol, the proposed benefits are very encouraging.  The medical field has shown a recent increase in attention with CBN, as the every-day person are taking note of the therapeutic effects.

References
https://thesleepdoctor.com/2018/10/03/is-cbn-the-next-big-thing-in-cannabis-therapy-for-sleep-mood-and-health/?cn-reloaded=1
https://www.leafly.com/news/science-tech/what-is-cbn-and-what-are-the-benefits-of-this-cannabinoid
https://www.psychologytoday.com/us/blog/sleep-newzzz/201908/research-shows-9-potential-health-benefits-cbn

CBG

CBG

Over the past 70 years, science has continued to propel cannabis to the forefront of our everyday lives, not to mention, science has been one of the greatest truth advocates for cannabis.  The discovery of cannabinoids and a scientific understanding of how they affect the body have been vital to the cannabis world.  Dating back to the 1960’s, scientists were able to separate the individual cannabinoids and study each one of those cannabinoids with greater detail.  Major cannabinoids such as CBD and THC were isolated while additional cannabinoids such as CBG, CBC, CBN and many others, were also identified. This gave researchers a platform to truly grasp the nature of each compound. One in particular, CBG, will be in the subject of this article. Before we go into too much detail, let’s give a little recap on how cannabinoids work.

By definition, cannabinoids are chemical compounds produced by the cannabis flowers. They work their magic by interacting with the Endocannabinoid system, a network of receptors found in the central & peripheral nervous systems, brain, immune cells, fat, and muscle. This correspondence plays a crucial role in your body’s biological functions, affecting sleep, pain, inflammation, etc… 

In 1964, Israeli researchers discovered the non-psychoactive compound known as CBG, the first cannabinoid to develop in cannabis at harvest, earning the nickname “The Mother of Cannabinoids”.  After discovery, the potential medicinal benefits of this cannabinoid were realized.

The human eye is full of endocannabinoid receptors, allowing cannabinoids to have a substantial impact on that area.  With this knowledge, CBG in particular is thought to hold a large influence amongst all cannabinoids.  By reducing intraocular pressure and accelerating the draining of eye fluids, conditions such as glaucoma may be alleviated. A study conducted by the Department of Ophthalmology at West Virginia Health Sciences Center North in Morgantown uncovered, “…Both CBG and THC produced a two-to-three-fold increase in aqueous outflow facility. These results suggest that cannabigerol (CBG) and related cannabinoids may have therapeutic potential for the treatment of glaucoma.”

Many also believe that CBG may carry anti-bacterial and anti-microbial properties. Research indicates that CBG may be one of the most effective mechanisms in combating methicillin-resistant Staphylococcus aureus, one of the most prevalent hospital superbugs. 

In addition, CBG’s ability to demonstrate anti-tumor properties look promising. Studies done by Cannabics Pharmaceuticals have shown encouraging results on human Gastrointestinal cancer cells. Dr. Eyal Ballan noted, “Gastrointestinal cancers are amongst the leading and most wide-spread causes of cancer-related deaths worldwide…We believe that these preliminary results vindicate our vision; which is to bring personalization into cannabinoid-based cancer treatments.”

Finally, CBG is thought to be effective as an appetite stimulant. In a study published by the US National Institute of Health, test subjects were given either a dosage of CBG or a placebo.  Subjects given CBG doubled their food intake.  No change occurred in the subjects given the placebo.  As research continues with this cannabinoid, the vast benefits are promising.  Although not as popular in the mainstream as it’s cousins, CBD or THC, the medical community has shown an increase in research focus with CBG, and other lesser known cannabinoids, and continue to unlock its therapeutic qualities.

References
https://www.ncbi.nlm.nih.gov/pubmed/1965836
https://cbdtesters.co/2019/12/09/can-cbg-be-the-answer-to-treating-glaucoma/
https://www.healtheuropa.eu/cannabinoids-cbc-and-cbg-exhibit-anti-tumour-properties-on-cancer-cells/97058/

The Difference: CBD Isolate vs Broad Spectrum

CBD Isolate VS Broad Spectrum

While looking at the Berkeley Gold product line, you’ve probably noticed the labels “Broad Spectrum” and “Isolate”.  Although the terms may be confusing, we make it our priority to educate our consumers. We want you to have the knowledge to choose the most appropriate type and/or delivery method of CBD available to fit your needs! In a nutshell, broad spectrum and isolate are used to define which type of CBD is in the product, although each is different.

Scientifically speaking, CBD isolate is the purest form of the compound. The other cannabinoids have been removed and an isolated CBD molecule is left. If you enjoy the benefits of straight CBD , this option will probably fit your needs. While looking at isolate and any other form of CBD , it’s especially important to take note of the purity. Here at Berkeley Gold, transparency is in full effect with Certificate of Analysis reports being readily available from every batch of product produced, being that our commitment to quality is second to none. In addition, we indicate the type of CBD used on each product. Whether it’s isolate or broad spectrum, you will know what’s in your purchase!

The cannabis plant contains a multitude of additional cannabinoids besides just CBD. Broad Spectrum has those other 100+ active phytochemicals (CBG, CBN, CBC, terpenes, healthy fatty acids, phytonutrients, etc…..) but has 0% THC.  The term “entourage effect” is commonly thrown around in the CBD space. This phrase refers to the synergetic interaction among the cannabinoids, terpenes, & other healthy fatty acids. In other words, the combination creates a unique mental or physical impact not afforded when only one compound is used alone.  Let’s use an example of a football team, with the quarterback being CBD. By himself, the quarterback plays arguably the most important role on the team, but he cannot win ballgames alone. He needs the help of his wide receivers, offensive line, defense, special teams, etc….. The other players represent the cannabinoids and additional compounds, playing vital roles on the team by causing their own unique effects. We can compare this football example to the entourage effect of having all “teammates” working together.

We should note that no type of CBD is better or worse than the other. It’s a matter of individual circumstances and finding out what works best for you.

If you have any questions, feel free to ask in the comment section below!

References
https://cbdoilusers.com/full-spectrum-cbd-oil-vs-isolate/

How Does CBD Work?

How Does CBD Work

As students, we were taught about the anatomy of the human body and the major organ systems inside all of us. They consist of skeletal, muscular, digestive, circulatory, urinary, respiratory, reproductive, nervous, endocrine, lymphatic, and integumentary systems. Did you know we also have another system inside that also allows us to maintain optimal health? This system is called the Endocannabinoid system,  a network of receptors found in the central & peripheral nervous systems, brain, immune cells, fat, and muscle that interact with receptors found in cannabinoids. The Endocannabinoid System is made up of three parts: endocannabinoids, receptors, and enzymes.  This system was first discovered in the 1990’s by scientists who were seeking to identify how THC affected the body. Through their research, they uncovered this intricate system of receptors displayed in the nervous system. They also identified the structure of the CB1 and CB2 receptors.  

Scientists have concluded that the Endocannabinoid System plays an essential role in our body’s biological functions. The ECS promotes homeostasis, which affects sleep, inflammation, pain, and other bodily functions and allows the body to operate at an optimal level.  The term “homeostasis” gets thrown around quite a bit, so it is necessary to explain the concept in more detail from a biological perspective. Homeostasis refers to the body’s ability to maintain a balanced internal environment, notwithstanding changes that occur outside of the body. The regulation of one’s body temperature through sweat or the thirsty feeling one gets after eating salty foods are examples of homeostasis. Both instances show your body’s desire to keep a stable condition. In addition, main organs such as skin, lungs, muscles, kidneys, etc…. are involved in homeostasis. With that being said, let’s dive into how endocannabinoids and cannabinoids, such as CBD, come into play.

Endocannabinoids are molecules produced within the body. They keep all internal functions running smoothly and allow for homeostasis, which is clearly essential for health and survival, as mentioned above. Endocannabinoids bind to the (CB1 and CB2) receptors throughout the body, which allows the Endocannabinoid System to take action and cause a desired effect. We can think of receptors as (natural) locks and the endocannabinoids as the keys. For example, endocannabinoids target the CB1 receptors located in the spine to relieve pain. Finally, the enzymes break down the endocannabinoids after they’ve carried out their task. This prevents the endocannabinoids from “going too far” and disrupting the balance in the opposite  direction. 

This is where cannabinoids such as CBD take shape, also binding to the receptors and affecting the body. After entering the body, CBD can bind to and interact with the CB1 receptors in the brain/central nervous system and the CB2 receptors scattered throughout the body. As a result, the Endocannabinoid System is able to function at a necessary level.

References
Cannabidiol (CBD) – what we know and what we don’t’ (2019) https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476
7 Benefits and Uses of CBD Oil (Plus Side Effects) https://www.healthline.com/nutrition/cbd-oil-benefits
Human Endocannabinoid System https://www.uclahealth.org/cannabis/human-endocannabinoid-system
The Endocannabinoid System https://www.projectcbd.org/science/endocannabinoid-system

What is CBD?

What is CBD

CBD (Cannabidiol) is one of the key naturally occurring cannabinoids (chemical compounds) found in the stocks, flowers, and seeds of the cannabis plant.  The cannabis plant has two main species, hemp and marijuana. Hemp has a much higher percentage of CBD, but less than .3% THC. Marijuana typically has low levels of CBD and a high percentage of THC. Therefore, CBD extracted from hemp lacks the intoxicating and psychoactive properties associated with the “high” of marijuana. Users report a multitude of benefits from the use of CBD including a sense of calmness, decrease in inflammation, stress relief, improvements in sleep quality, etc…

Our 100% USA organic hemp derived products begin their journey from an ISO 9001 and GMP certified extraction facility. From there, our products are manufactured and packaged at our licensed pharmaceutical manufacturing facility. At Berkeley Gold, our entire process from plant to finished product assures consistency, as well as strict regulatory and customer requirements.

References
Cannabidiol (CBD) https://www.webmd.com/vitamins/ai/ingredientmono-1439/cannabidiol-cbd